Plant source: Andrographis paniculata

Andrographolide is a labdane diterpenoid that is the main bioactive component of the medicinal plant Andrographis paniculata. Andrographolide is an extremely bitter substance extracted from the leaves of A. paniculata.

Andrographolide is used experimentally in different areas of research including cell signaling, immunomodulation, and stroke.

Plant source: Colchicum autumnale

Colchicine is a medication most commonly used to treat gout. It is extracted from plants of the genus Colchicum (autumn crocus, Colchicum autumnale, also known as “meadow saffron”).

Colchicine is an alternative for those unable to tolerate NSAIDs in gout

Plant source: Coleus forskohlii

Forskolin (also called Coleonol) is a labdane diterpene that is produced by the Indian Coleus plant (Coleus forskohlii). Forskolin is commonly used to raise levels of cyclic AMP (cAMP) in the study and research of cell physiology. Forskolin activates the enzyme adenylyl cyclase and increases intracellular levels of cAMP.

Forskolin is also used in cosmetic formulations.

Plant source: Glycyrrhiza glabra

Glabridin (is a chemical compound that is found in the root extract of licorice (Glycyrrhiza glabra). Glabridin is an isoflavane, a type of isoflavonoid. This product is part of a larger family of plant-derived molecules, the natural phenols.

It is used as an ingredient in cosmetics and is listed in International Nomenclature of Cosmetic Ingredients (INCI).

Plant source: Sesamum indicum

Sesamin is a lignan isolated from the sesame oil. It has been used as a dietary fat-reduction supplement, Sesamin and sesamolin are minor components of sesame oil, on average comprising only 0.14% of the oil by mass

Plant source: Gloriosa superba

Thiocolchicoside, a semisynthetic colchicoside from the plant Gloriosa superba, is a muscle relaxant and used to treat rheumatologic and orthopedic disorders because of its analgesic and anti-inflammatory mechanisms.

Plant source : Withania somnifera

Withaferin A is a steroidal lactone isolated from Winter cherry (Withania somnifera) and is the first member of the withanolides to be discovered. Withaferin A is a potent inhibitor of angiogenesis (the formation of new blood vessels). Withaferin A inhibits both NF-κB and Sp1 Transcription factor activity. Withaferin A also down regulates VEGF gene expression and can affect calcium signaling.